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價格：電議
所在地：福建 廈門市
型號：
更新時間：2018-08-27
瀏覽次數：2503
公司地址：廈門市湖里區長浩一里59#702
陳(先生)
關于慧嘉
廈門慧嘉生物科技有限公司，是一家專業代理國內外知名品牌生命科學試劑產品，產品范圍涉及細胞生物學，分子生物學，免疫學及生物化學等實驗室科學研究試劑，包括細胞系，細胞培養，ELISA和免疫組化抗體，一抗，二抗，單克隆和多克隆抗體，PCR及放免試劑盒，生化試劑以及各類實驗儀器。
公司成立以來，一群有志的年輕人本著始終擁有的創業激情，注重跟蹤世界范圍分子生物學、細胞生物學等生物學科的發展前沿，努力將歐美專業生產廠家的具有國際先進水平的產品推薦給各類研究人員。已被廣泛應用于生命科學基礎研究、開發應用、制藥、疾病診斷與控制、人口與健康、生物技術等諸多領域。客戶遍布大學、研究所、醫院、衛生防疫、商品檢驗檢疫、制藥公司、生物技術公司和食品工業等單位。
公司在重視產品質量的同時，也建立了一套集技術支持、物流、售后服務等多個部門的全方位的服務體系，努力把我們方便、快捷、周到的服務提供給每一個客戶。
我們熱誠希望與廣大用戶朋友攜手合作，為推動中國的科技發展盡上一份綿薄之力！
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誠信是金、信用第一，努力成為國內外生命科學和生物技術行業的信用企業。
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為生命科研工作者和人類健康提供優質的產品和服務，成為您實驗身邊的好伙伴。
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忠誠、敢為、勤奮、成功
| Catalogue Number | CYT-107 |
| Synonyms | SYM1, SYNS1, NOG. |
| Introduction | The secreted polypeptide noggin, encoded by the NOG gene, binds and inactivates members of the transforming growth factor-beta (TGF-beta) superfamily signaling proteins, such as bone morphogenetic protein-4 (BMP4). By diffusing through extracellular matrices more efficiently than members of the TGF-beta superfamily, noggin may have a principal role in creating morphogenic gradients. Noggin appears to have pleiotropic effect, both early in development as well as in later stages. It was originally isolated from Xenopus based on its ability to restore normal dorsal-ventral body axis in embryos that had been artificially ventralized by UV treatment. The results of the mouse knockout of noggin suggest that it is involved in numerous developmental processes, such as neural tube fusion and joint formation. Recently, several dominant human NOG mutations in unrelated families with proximal symphalangism (SYM1) and multiple synostoses syndrome (SYNS1) were identified; both SYM1 and SYNS1 have multiple joint fusion as their principal feature, and map to the same region (17q22) as NOG. All NOG mutations altered evolutionarily conserved amino acid residues. The amino acid sequence of human noggin is highly homologous to that of Xenopus, rat and mouse. |
| Description | Noggin Human Recombinant produced in HEK cells is a glycosylated homodimer, having a total molecular weight of 65kDa. The Noggin is purified by proprietary chromatographic techniques. |
| Source | HEK. |
| Physical Appearence | Sterile Filtered White lyophilized (freeze-dried) powder. |
| Formulation | The Noggin was lyophilized from 1mg/ml in 1xPBS. |
| Solubility | It is recommended to reconstitute the lyophilized Noggin in sterile water not less than 100µg/ml, which can then be further diluted to other aqueous solutions. |
| Stability | Lyophilized Noggin although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution Noggin should be stored at 4°C between 2-7 days and for future use below -18°C. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Please prevent freeze-thaw cycles. |
| Purity | Greater than 95% as obsereved by SDS-PAGE. |
| Biological Activity | The specific activity was determined by the dose dependent inhibition of rhBMP4 induced alkaline phosphate production by ATDC5 cells and is typically 20-100ng/ml. |
| Usage | ProSpecs products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals. |
免責聲明：以上所展示的[ 重組人頭蛋白, HEK來源/Noggin Human, HEK]信息由會員[廈門慧嘉生物科技有限公司]自行提供，內容的真實性、準確性和合法性由發布會員負責。
