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"上海博耀生物銷售SRC-3 (11B1) Mouse mAb #2115，CST原裝品質(zhì)，價(jià)格優(yōu)惠，訂購(gòu)SRC-3 (11B1) Mouse mAb #2115，詳情請(qǐng)咨詢銷售人
產(chǎn)品說(shuō)明
"上海博耀生物銷售
SRC-3 (11B1) Mouse mAb #2115，CST原裝品質(zhì)，價(jià)格優(yōu)惠，訂購(gòu)
SRC-3 (11B1) Mouse mAb #2115，詳情請(qǐng)咨詢銷售人員！
產(chǎn)品詳細(xì)參數(shù)如下>>>>
產(chǎn)品名稱：SRC-3 (11B1) Mouse mAb #2115
貨號(hào)：2115
品牌：CST(cell signaling)
抗體來(lái)源：Mouse
克隆類型：
Monoclonal
規(guī)格：
| No. |
Size |
Price |
| 2115S |
100 ul (10 western blots) |
詢價(jià) |
抗體應(yīng)用：
| Applications |
Reactivity |
Sensitivity |
MW (kDa) |
Isotype |
| W IF-IC F |
H |
Endogenous |
160 |
Mouse IgG1 |
Applications Key:
W=Western Blotting
IF-IC=Immunofluorescence (Immunocytochemistry)
F=Flow Cytometry
Reactivity Key:
H=Human
Species cross-reactivity is determined by western blot. Species enclosed in parentheses are predicted to react based on sequence homology.
特異性/敏感度：
SRC-3 (11B1) Mouse mAb detects endogenous levels of total SRC-3 protein.
來(lái)源及純化方法：
Monoclonal antibody is produced by immunizing animals with recombinant human SRC-3 polypeptide fragment (a.a. 1-250).
抗體背景：
There are three members of the steroid receptor co-activator (SRC) family of proteins: SRC-1 (NCoA-1), SRC-2 (TIF2/GRIP1/NCoA-2), and SRC-3 (ACTR/pCIP/RAC3/TRAM-1/AIB1). All SRC family members share significant structural homology and function to stimulate transcription mediated by nuclear hormone receptors and other transcriptional activators such as Stat3, NF-κB, E2F1, and p53 (1-4). Two SRC proteins, SRC-1 and SRC-3, function as histone acetyltransferases (5,6). In addition, all three family members can recruit other histone acetyltransferases (CBP/p300, PCAF) and histone methyltransferases (PRMT1, CARM1) to target promoters and cooperate to enhance expression of many genes (5-8). The SRC proteins play important roles in multiple physiological processes including cell proliferation, cell survival, somatic cell growth, mammary gland development, female reproductive function, and vasoprotection (9). SRC-1 and SRC-3 are conduits for kinase-mediated growth factor signaling to the estrogen receptor and other transcriptional activators. Seven SRC-1 phosphorylation sites and six SRC-3 phosphorylation sites have been identified, which are induced by steroids, cytokines, and growth factors and involve multiple kinase signaling pathways (9-11). Research has shown that all three SRC family members are associated with increased activity of nuclear receptors in breast, prostate, and ovarian carcinomas. According to the literature, SRC-3 is frequently amplified or overexpressed in a number of cancers (12), and SRC-1/PAX3 and SRC-2/MYST3 translocations are found associated with rhabdomyosarcoma and acute myeloid leukemia, respectively (13,14).
關(guān)鍵詞：CST，抗體，一抗{byao_back}{byao_back2}
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