產(chǎn)品簡介
"上海博耀生物銷售Phospho-IKKα (Ser176)/IKKβ (Ser177) (C84E11) Rabbit mAb #2078，CST原裝品質(zhì)，價格優(yōu)惠，訂購Phospho-IKK
產(chǎn)品說明
"上海博耀生物銷售
Phospho-IKKα (Ser176)/IKKβ (Ser177) (C84E11) Rabbit mAb #2078，CST原裝品質(zhì)，價格優(yōu)惠，訂購
Phospho-IKKα (Ser176)/IKKβ (Ser177) (C84E11) Rabbit mAb #2078，詳情請咨詢銷售人員！
產(chǎn)品詳細參數(shù)如下>>>>
產(chǎn)品名稱：Phospho-IKKα (Ser176)/IKKβ (Ser177) (C84E11) Rabbit mAb #2078
貨號：2078
品牌：CST(cell signaling)
抗體來源：Rabbit
克隆類型：
Monoclonal
規(guī)格：
| No. |
Size |
Price |
| 2078P |
40 ul (4 western blots) |
詢價 |
| 2078S |
100 ul (10 western blots) |
詢價 |
抗體應(yīng)用：
| Applications |
Reactivity |
Sensitivity |
MW (kDa) |
Isotype |
| W |
H M (R) (Mk) (B) |
Endogenous |
85 (IKKalpha), 87 (IKKbeta) |
Rabbit IgG |
Applications Key:
W=Western Blotting
Reactivity Key:
H=Human
M=Mouse
R=Rat
Mk=Mon
key
B=Bovine
Species cross-reactivity is determined by western blot. Species enclosed in parentheses are predicted to react based on sequence homology.
特異性/敏感度：
Phospho-IKKα (Ser176)/IKKβ (Ser177) (C84E11) Rabbit mAb detects endogenous levels of IKKα and IKKβ only when phosphorylated at Ser176 and Ser177, respectively.
來源及純化方法：
Monoclonal antibody is produced by immunizing animals with a synthetic phosphopeptide corresponding to residues surrounding Ser177 of IKKβ.
抗體背景：
The NF-κB/Rel transcription factors are present in the cytosol in an inactive state, complexed with the inhibitory IκB proteins (1-3). Most agents that activate NF-κB do so through a common pathway based on phosphorylation-induced, proteasome-mediated degradation of IκB (3-7). The key regulatory step in this pathway involves activation of a high molecular weight IκB kinase (IKK) complex whose catalysis is generally carried out by three tightly associated IKK subunits. IKKα and IKKβ serve as the catalytic subunits of the kinase and IKKγ serves as the regulatory subunit (8,9). Activation of IKK depends upon phosphorylation at Ser177 and Ser181 in the activation loop of IKKβ (Ser176 and Ser180 in IKKα), which causes conformational changes, resulting in kinase activation (10-13).
關(guān)鍵詞：CST，抗體，一抗{byao_back}{byao_back2}
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2078 Phospho-IKKα (Ser176)/IKKβ (Ser177) (C84E11) Rabbit mAb #2078]信息由會員[
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