產品簡介
"上海博耀生物銷售Mena Antibody #2075，CST原裝品質，價格優惠，訂購Mena Antibody #2075，詳情請咨詢銷售人員！產品詳細參數如
產品說明
"上海博耀生物銷售
Mena Antibody #2075，CST原裝品質，價格優惠，訂購
Mena Antibody #2075，詳情請咨詢銷售人員！
產品詳細參數如下>>>>
產品名稱：Mena Antibody #2075
貨號：2075
品牌：CST(cell signaling)
抗體來源：Rabbit
克隆類型：
Polyclonal
規格：
| No. |
Size |
Price |
| 2075S |
100 ul (10 western blots) |
詢價 |
抗體應用：
| Applications |
Reactivity |
Sensitivity |
MW (kDa) |
Source |
| W |
H M R |
Endogenous |
80, 88, 140 |
Rabbit |
Applications Key:
W=Western Blotting
Reactivity Key:
H=Human
M=Mouse
R=Rat
Species cross-reactivity is determined by western blot. Species enclosed in parentheses are predicted to react based on sequence homology.
特異性/敏感度：
Mena Antibody detects endogenous levels of total Mena protein.
來源及純化方法：
Polyclonal antibodies are produced by immunizing animals with a synthetic peptide of human Mena. Antibodies are purified by protein A and peptide affinity chromatography.
抗體背景：
Mena (mammalian enabled), EVL, and VASP are members of the Ena/VASP family, which is involved in controlling cell shape and cell movement by shielding actin filaments from capping proteins (1). Ena/VASP proteins have three specific domains: an amino-terminal EVH1 domain controlling protein localization; a central proline-rich domain mediating interactions with both SH3 and WW domain containing proteins, including profilin; and a carboxy-terminal domain causing tetramerization and binding to actin (2). Mena interacts with actin filaments at the growing ends localizing to lamellipodia and to tips of growth cone filopodia in neurons. Axons projecting from interhemispheric cortico-cortical neurons are misrouted in newborn, homozygous Mena knock-out mice (3). Mena is phosphorylated at Ser236 by PKA, thereby promoting filopodial formation and elongation in the growth cone (4).Three forms of Mena corresponding to 80, 88 and 140 kD are known. The 80 kD protein is broadly expressed in contrast to the 140 kD protein which is enriched in neural cell types. Alternative splicing produces these forms. The 88 kD protein is mainly found in embryonic cell types and is likely the result of post-translational modification. Expression of all three forms is completely eliminated in Mena homozygous mutant animals (1, 3).
關鍵詞：CST，抗體，一抗{byao_back}{byao_back2}
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