產品簡介
"上海博耀生物銷售PKCα Antibody #2056，CST原裝品質，價格優惠，訂購PKCα Antibody #2056，詳情請咨詢銷售人員！產品詳細參數
產品說明
"上海博耀生物銷售
PKCα Antibody #2056，CST原裝品質，價格優惠，訂購
PKCα Antibody #2056，詳情請咨詢銷售人員！
產品詳細參數如下>>>>
產品名稱：PKCα Antibody #2056
貨號：2056
品牌：CST(cell signaling)
抗體來源：Rabbit
克隆類型：
Polyclonal
規格：
| No. |
Size |
Price |
| 2056P |
40 ul (4 western blots) |
詢價 |
| 2056S |
100 ul (10 western blots) |
詢價 |
抗體應用：
| Applications |
Reactivity |
Sensitivity |
MW (kDa) |
Source |
| W IP IF-IC F |
H M R Mk (Dg) |
Endogenous |
80 |
Rabbit |
Applications Key:
W=Western Blotting
IP=Immunoprecipitation
IF-IC=Immunofluorescence (Immunocytochemistry)
F=Flow Cytometry
Reactivity Key:
H=Human
M=Mouse
R=Rat
Mk=Mon
key
Dg=Dog
Species cross-reactivity is determined by western blot. Species enclosed in parentheses are predicted to react based on sequence homology.
特異性/敏感度：
PKCalpha Antibody detects endogenous levels of total PKCα protein. The antibody does not cross-react with endogenous levels of other PKC isoforms.
來源及純化方法：
Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to human PKCα. Antibodies are purified by protein A and peptide affinity chromatography.
抗體背景：
Activation of protein kinase C (PKC) is one of the earliest events in a cascade that controls a variety of cellular responses, including secretion, gene expression, proliferation, and muscle contraction (1,2). PKC isoforms belong to three groups based on calcium dependency and activators. Classical PKCs are calcium-dependent via their C2 domains and are activated by phosphatidylserine (PS), diacylglycerol (DAG), and phorbol esters (TPA, PMA) through their cysteine-rich C1 domains. Both novel and atypical PKCs are calcium-independent, but only novel PKCs are activated by PS, DAG, and phorbol esters (3-5). Members of these three PKC groups contain a pseudo-substrate or autoinhibitory domain that binds to substrate-binding sites in the catalytic domain to prevent activation in the absence of cofactors or activators. Control of PKC activity is regulated through three distinct phosphorylation events. Phosphorylation occurs in vivo at Thr500 in the activation loop, at Thr641 through autophosphorylation, and at the carboxy-terminal hydrophobic site Ser660 (2). Atypical PKC isoforms lack hydrophobic region phosphorylation, which correlates with the presence of glutamic acid rather than the serine or threonine residues found in more typical PKC isoforms. The enzyme PDK1 or a close relative is responsible for PKC activation. A recent addition to the PKC superfamily is PKCμ (PKD), which is regulated by DAG and TPA through its C1 domain. PKD is distinguished by the presence of a PH domain and by its unique substrate recognition and Golgi localization (6). PKC-related kinases (PRK) lack the C1 domain and do not respond to DAG or phorbol esters. Phosphatidylinositol lipids activate PRKs, and small Rho-family GTPases bind to the homology region 1 (HR1) to regulate PRK kinase activity (7).
關鍵詞：CST，抗體，一抗{byao_back}{byao_back2}
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