脫氧胞苷激酶抗體用途
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- 更新日期：2021-12-24 14:20
- 瀏覽次數：351 下載次數：324
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詳細介紹
中文名稱 脫氧胞苷激酶抗體
英文名稱 DCK
別 名 DCK; dCK; DCK protein; DCK_HUMAN; Deoxycytidine kinase; EC 2.7.1; EC 2.7.1.74; MGC117410; MGC138632; OTTHUMP00000219118; OTTHUMP00000219119.
規 格 0.2ml
研究領域 腫瘤 染色質和核信號 信號轉導 細胞周期蛋白 激酶和磷酸酶
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應 Human, Mouse, Rat, Pig, Horse,
產品應用 WB=1:100-500 ELISA=1:500-1000 IP=1:20-100 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 脫氧胞苷激酶抗體（石蠟切片需做抗原修復）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 31kDa
性 狀 Lyophilized or Liquid
濃 度 1mg/1ml
免 疫 原 KLH conjugated synthetic peptide derived from human DCK
亞 型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M PBS, pH 7.4 with 10 mg/ml BSA and 0.1% Sodium azide
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
脫氧胞苷激酶抗體產品介紹 background:
Deoxycytidine kinase is responsible for the phosphorylation of several deoxyribonucleosides and their analogs. Deficiency of this enzyme activity is associated with resistance to antiviral and anticancer chemotherapeutic agents, whereas increased enzyme activity is associated with increased activation of these compounds to cytotoxic nucleoside triphosphate derivatives. It is the rate limiting enzyme in the activation of many important anticancer and retroviral drugs and its activity is often decreased in cells that are resistant to cytosine arabinoside.
Function:
Required for the phosphorylation of the deoxyribonucleosides deoxycytidine (dC), deoxyguanosine (dG) and deoxyadenosine (dA). Has broad substrate specificity, and does not display selectivity based on the chirality of the substrate. It is also an essential enzyme for the phosphorylation of numerous nucleoside analogs widely employed as antiviral and chemotherapeutic agents.
Subunit:
Homodimer.
Subcellular Location:
Nucleus.
Post-translational modifications:
Phosphorylated and activated in vitro upon phosphorylation at Ser-74 by CSNK1D/CK1.
Similarity:
Belongs to the DCK/DGK family.
Database links:
UniProtKB/Swiss-Prot: P27707.1
important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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