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無精癥缺失基因1抗體產品介紹

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更新日期：2021-11-25 16:38
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詳細介紹

英文名稱 Anti-DAZ1
中文名稱無精癥缺失基因1抗體
別    名 DAZ 1; DAZ; Deleted in azoospermia 1; Deleted in azoospermia; Deleted in azoospermia protein 1; SPGY; DAZ1_HUMAN.
濃    度 1mg/1ml
規格 0.2ml/200μg
抗體來源 Rabbit
克隆類型 polyclonal
交叉反應 Human, Mouse, Rat, Dog, Cow, Horse, Rabbit, Sheep
產品類型一抗
研究領域細胞生物發育生物學信號轉導干細胞表觀遺傳學
蛋白分子量 predicted molecular weight: 83kDa
性    狀 Lyophilized or Liquid
免疫原 KLH conjugated synthetic peptide derived from Human DAZ1
亞    型 IgG
純化方法 affinity purified by Protein A
儲存液 Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4
產品應用   WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500
（石蠟切片需做抗原修復）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.

保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

important Note This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

無精癥缺失基因1抗體產品介紹 DAZ1 (deleted in azoospermia 1) is an RNA-binding protein that is essential in spermatogenesis. It may regulate translation of mRNAs by binding to the 3'-UTR.

Function : RNA-binding protein that plays an essential role in spermatogenesis. May act by binding to the 3'-UTR of mRNAs and regulating their translation. Promotes germ-cell progression to meiosis and formation of haploid germ cells.
Subunit : Forms a heterodimer with BOLL and DAZL. Interacts with PUM2, DAZAP1, DAZAP2, DZIP1 and DZIP3.
Subcellular Location : Cytoplasmic and Nuclear.Note=Predominantly cytoplasmic. Nuclear at some stages of spermatozoide development. Localizes both to the nuclei and cytoplasm of spermatozoide differentiation. Nuclear in fetal gonocytes and in spermatogonial nuclei. It then relocates to the cytoplasm during male meiosis.

Tissue Specificity : Testis-specific. expression restricted to premeiotic germ cells, particularly in spermatogonia (at protein level).
DISEASE : Defects in DAZ1 may be a cause of spermatogenic failure Y-linked type 2 (SPGFY2) [MIM:415000]. It is a disorder resulting in the absence (azoospermia) or reduction (oligozoospermia) of sperm in the semen, leading to male infertility. Note=AZFc deletions in the Yq11.23 region including the DAZ genes are the most common known genetic cause of human male infertility.

Similarity : Belongs to the RRM DAZ family.
Contains 9 DAZ-like domains.
Contains 3 RRM (RNA recognition motif) domains.
Database links : UniProtKB/Swiss-Prot: Q9NQZ3.2