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細胞膜蛋白Derlin抗體簡介

文件類型：Word文檔
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更新日期：2021-11-12 16:17
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詳細介紹

中文名稱    細胞膜蛋白Derlin抗體
英文名稱    DERLIN-1
別    名    Derlin1; Derlin1; Derlin 1; DER1; DER-1; DER 1; DERL1_HUMAN.
研究領域    細胞生物細胞膜蛋白
抗體來源    Rabbit
克隆類型    Polyclonal
交叉反應    Human, Mouse, Rat, Dog, Cow, Horse, Rabbit, Sheep,
產品應用    ELISA=1:500-1000 IHC-P=1:400-800 IHC-F=1:400-800 ICC=1:100-500 IF=1:100-500 （石蠟切片需做抗原修復）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分子量    29kDa
細胞定位    細胞漿細胞膜
性    狀    Lyophilized or Liquid
濃    度    1mg/ml
免疫原    KLH conjugated synthetic peptide derived from human DERLIN-1:111-220/251
亞    型    IgG
純化方法    affinity purified by Protein A
儲存液    0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件    Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

產品介紹    Degradation in endoplasmic reticulum proteins, also designated Derlins or DERtrins, are crucial for the degradation of misfolded endoplasmic reticulum (ER) luminal proteins. Derlin proteins are multi-pass membrane proteins localizing to the ER. Derlins are involved in transferring misfolded proteins from the ER to the cytosol, where the misfolded proteins are destroyed in an ubiquitin-dependent manner by the proteasome. In the case of cytomegalovirus infection, Derlin-1, as opposed to Derlins-2 and -3, is involved in the export of MHC class I heavy chains from the ER via its interaction with the viral protein US11. Derlins may also be important for cell proliferation.